What is Hydroxychloroquine?
Hydroxychloroquine, marketed under the brand name Plaquenil among others, is a drug used for the prevention and treatment of malaria in places where malaria remains chloroquine responsive. Certain applications include treating rheumatoid arthritis, lupus, and cutanea tarda porphyria. It’s mouth-taking.
Coronavirus patients who took hydroxychloroquine, a treatment recomeded by Trump, were less likely to require ventilator and had higher mortality rates compared to those who did not, according to a study of hundreds of patients at centers medical United States Veterans Health Administration. .
The study, which reviewed veterans’ medical charts, was posted Tuesday on medrxiv.org, a pre-print server, meaning it has not been peer reviewed or published in a medical journal. The research was funded by the National Institutes of Health and the University of Virginia.
In the study of 368 patients, 97 patients who took hydroxychloroquine had a death rate of 27.8%. The 158 patients who did not take the drug had a death rate of 11.4%.
“An association of increased overall mortality in patients treated with hydroxychloroquine alone has been identified. These findings highlight the importance of awaiting the results of prospective, randomized, controlled studies before widespread adoption of these drugs. , ”wrote the authors, who work at the Columbia. VA Healthcare System in South Carolina, University of South Carolina and University of Virginia.
Researchers also looked at whether taking hydroxychloroquine or a combination of hydroxychloroquine and the antibiotic azithromycin, had an impact on whether a patient needed to go on a ventilator.
“In this study, we found no evidence that using hydroxychloroquine, either with or without azithromycin, reduces the risk of mechanical ventilation in hospitalized patients with Covid-19,” the authors wrote.
There are currently no products approved by the US Food and Drug Administration to prevent or treat Covid-19, although research is underway on many drugs.
Hydroxychloroquine has been used for decades to treat patients with diseases such as malaria, lupus and rheumatoid arthritis. Trump has touted the drug as a “game changer” for Covid-19 and said hydroxychloroquine shows “tremendous promise.”
Doctors have warned that while Trump is passionate about the drug, it still needs to be studied to see if it works and whether it is safe.
In another recent study, researchers in France examined medical records for 181 Covid-19 patients who had pneumonia and who needed supplemental oxygen. About half had taken hydroxychloroquine within 48 hours of hospital admission, and the other half had not.
He found that there was no statistically significant difference in the death rates of the two groups, or their chances of admission to the intensive care unit. However, he found that eight patients who took the drug developed abnormal heart rhythms and had to stop taking it. Also this research has not been peer reviewed or published in a medical journal.
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REF : CNN